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KMID : 0603520040090020084
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Journal of Korean Association of Cancer Prevention
2004 Volume.9 No. 2 p.84 ~ p.91
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Cancer Preventive Effects of Saengshik, a Formulated Health Food, Prepared with Pine Needle
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Kil Jeung-Ha
Kong Chang-Suk
Moon Suk-Hee
Park Kun-Young
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Abstract
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Antimutagenic effects of methanol extracts from various kinds of vegetables were evaluated to develop Saengshik having cancer preventive effect. Among the various kinds of vegetables, pine needle showed the highest antimutagenic activity. Thus, the Saengshik recipes were prepared by adding different levels of pine needle (2%, 6%, 10% and 20% level in Saengshik I, II, III and IV, respectively). Antimutagenic and anticlastogenic effects of methanol extracts from Saengshik were investigated using Ames test and supravital staining micronucleus assay in the ICR mice. Increased content of pine needle in the Saengshik led to high inhibitory effects on the carcinogens (MNNG and AFB1)- induced mutagenicities. In vivo anticlastogenic effects of the Saengshik (Saengshik I and III) were evaluated by supravital staining micronucleus assay in the ICR mice. The developed Saengshik significantly decreased mtomycin C - induced clastogenicity (p＜0.05). Among the Saengshik, Saengshik III containing 10% pine needle was the most effective.
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KEYWORD
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Pine needle, Saengshik, Antimutagenic effect, Anticlastogenic effects
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